• In Lee et al reported regulation

  2019-07-11

  

  In 2014, Lee et al., reported regulation of LIN28B protein level via ubiquitin-mediated proteasomal degradation and identified ubiquitin ligase TRIM71 as a negative regulator of LIN28B [21]. Mass spectrometry data followed by IP assays suggested a possible interaction between USP28 and LIN28A protei

• We reasoned that since many of the same stresses

  2019-07-11

  

  We reasoned that, since many of the same stresses against which AOX provides a defence in plants and lower eukaryotes also occur pathologically in humans, as a result of mitochondrial OXPHOS dysfunction, deploying aRC enzymes xenotopically might help alleviate the associated disease states [24]. To

• br Conclusions The search for

  2019-07-08

  

  Conclusions The search for in vitro systems to model liver physiology and pathophysiology has been a long and still incomplete quest. We have witnessed a considerable improvement in the last decade thanks to the opportunity to derive liver Etoposide from iPSC and to the generation of liver-tissu

• br Overview on neutral lipids of

  2019-07-08

  

  Overview on neutral lipids of the liver Neutral lipids are a group of lipid classes, which are all together uncharged and hydrophobic in nature. Historically they have been analyzed by one-dimensional thin layer chromatography using silica plates and a hydrophobic solvent system (e.g. hexane: die

• Previous studies showed that SIRT is involved in gene silenc

  2019-07-08

  

  Previous studies showed that SIRT1 is involved in gene silencing and expression, tissue differentiation, cell survival and apoptosis, metabolism, and senescence [7]. Moreover, the upregulation of SIRT1 in cardiomyocytes can inhibit apoptosis, protect against oxidative stress, and inhibit senescence

• Genetic defects involving enzymes essential for pyrimidine n

  2019-07-08

  

  Genetic defects involving enzymes essential for pyrimidine nucleotide metabolism have provided insights into the vital physiological functions of these molecules [1,3,6]. Inherited disorders of pyrimidine metabolism have a wide variety of clinical presentations which include, among others, anaemia,

• br Methods br Results br Discussion As illustrated in Fig

  2019-07-06

  

  Methods Results Discussion As illustrated in Fig. 8, the present study shows (i) that decreased ABCA1 expression and subsequent increased intracellular Cho occur in aging mice, (ii) that the increased intracellular Cho enhances ENaC activity by promoting the interaction between ENaC and its

• The seven mammalian sirtuins SIRT SIRT

  2019-07-06

  

  The seven mammalian sirtuins, SIRT1-SIRT7, hold differences in subcellular location and function. SIRT1, SIRT6 and SIRT7 are predominately located in the nucleus. These three nuclear sirtuins act as transcription regulators, and are involved in additional regulatory activities including Ezatiostat

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