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  • br Table br Estimated proportion and numbers of cancer cases

    2020-08-28


    Table 2
    Estimated proportion (%) and numbers of cancer cases attributable to insufficient physical activity in France in 2015, by sex, cancer site and reference.
    Men
    Women
    Both sexes
    Breast (postmenopausal)
    Colon
    Breast (postmenopausal)
    Breast (postmenopausal)
    a Proportion out of all cancer cases (excluding non-melanoma skin cancers). b Totals may differ because of rounding. c Half of the recommended level of physical activity in France.
    estimate the effects of sedentary behaviour that includes very low-in-tensity activities. However, while there has been less research on se-dentary behaviour and cancer risk, there is accumulating evidence that sedentary behaviour is associated with an increased risk of several cancers [3,22] – something that should be considered in futures studies. Also, only the direct effect of insufficient physical activity on cancer occurrence was estimated in this study. Indirect effects, including mediation through co-factors such as obesity, may further increase our estimates. Fourth, the physical activity recommendations in the French Docetaxel were used to define the minimum risk exposure level, however this does not preclude that higher levels of total physical ac-tivity may provide additional optimum risk reduction for some cancer sites. Finally, the estimation of the PAF was based on the assumption that the association between insufficient physical activity and the stu-died cancer sites is causal [23]. We thus assume that increasing physical activity at the population level would lead to a decline in the incidence of these cancers.
    In conclusion, our study showed that insufficient physical activity is an important modifiable risk factor of cancer in France and further underpins the need for continuing targeted prevention efforts on the population level. In addition, lack of physical activity has also been causally associated with cardiovascular diseases, metabolic disorders, type 2 diabetes, depression and falls [24]. As a result, the decrease in the prevalence of insufficiently active persons would also decrease the burden of these diseases [25].
    Contributors
    MT, MA and IS contributed to data collection, study design, ana-lysis, and wrote the first draft of the paper. VD contributed to study design, data collection and finalising the report. LD, HF, FB and IM contributed to study design and drafting of the report. All authors read and approved the final report.
    Role of the funding source
    This work was funded by the French National Cancer Institute (INCa, grant nr. 2015-002). The funding source had no role in the collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. 
    Conflicts of interest statement
    None declared.
    Acknowledgements
    The authors would like to thank Catherine Hill from Institut Gustave Roussy (Villejuif) for critical input in several stages of the project and FRANCIM, Hospices Civils de Lyon and Florence de Maria (Santé Publique France) for the provision of the cancer Docetaxel data.
    Appendix A. Supplementary data
    References
    [1] Food, Nutrition, Physical activity, and the Prevention of Breast Cancer. Continuous Update Project Report, World Cancer Research Fund / American Institute for Cancer Research, 2010. [2] Food, Nutrition, Physical activity, and the Prevention of Colorectal Cancer. Continuous Update Project Report, World Cancer Research Fund / American Institute for Cancer Research, 2011. [3] Food, Nutrition, Physical activity, and the Prevention of Endometrial Cancer. Continuous Update Project Report, World Cancer Research Fund / American Institute for Cancer Research, 2013. [4] N. Keum, W. Ju, D.H. Lee, E.L. Ding, C.C. Hsieh, J.E. Goodman, et al., Leisure-time physical activity and endometrial cancer risk: dose-response meta-analysis of epi-demiological studies, Int. J. Cancer 135 (3) (2014) 682–694. [5] American Institute for Cancer Research, World Cancer Research Fund, Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective: A Project of World Cancer Research Fund International, American Institute for Cancer Research, Washington, D.C, 2007 xxv, 517 p..
    M. Touvier, et al., Alcoholic beverages, obesity, physical activity and other nutri-tional factors, and cancer risk: a short-day plants review of the evidence, Crit. Rev. Oncol. Hematol. 99 (2016) 308–323. [7] Nutrition et prévention primaire des cancers: actualisation des données, Boulogne-
    Billancourt: INCa, 2015 Available online at e-cancer.fr (French).
    M. Touillaud, et al.
    nutrition santé (ENNS, 2006) - Situation nutritionelle en France en 2006 selon les indicateurs d’objectif et les repères du Programme national nutrition santé (PNNS), Institut de veille sanitaire (InVS), Université de Paris 13, Conservatoire des arts et métiers, 2007.